The 2012 opponents for the St Louis Rams have been set, but the final schedule dates will be released by the NFL in mid-April. Please check back at that time for more information.
| EVENT | VENUE | DATE/TIME |
| St Louis Rams vs. Seattle Seahawks |
Edward Jones Dome St Louis, MO |
TBD |
| St Louis Rams vs. Arizona Cardinals |
Edward Jones Dome St Louis, MO |
TBD |
| St Louis Rams vs. San Francisco 49ers |
Edward Jones Dome St Louis, MO |
TBD |
| St Louis Rams vs. Chicago Bears |
Edward Jones Dome St Louis, MO |
TBD |
| St Louis Rams vs. Detroit Lions |
Edward Jones Dome St Louis, MO |
TBD |
| St Louis Rams vs. New England Patriots |
Edward Jones Dome St Louis, MO |
TBD |
| St Louis Rams vs. New York Jets |
Edward Jones Dome St Louis, MO |
TBD |
| St Louis Rams vs. Washington Redskins |
Edward Jones Dome St Louis, MO |
TBD |
| Seattle Seahawks vs. St Louis Rams |
CenturyLink Field Seattle, WA |
TBD |
| Arizona Cardinals vs. St Louis Rams |
University of Phoenix Stadium Glendale, AZ |
TBD |
| San Francisco 49ers vs. St Louis Rams |
Candlestick Park San Francisco, CA |
TBD |
| Green Bay Packers vs. St Louis Rams |
Lambeau Field Green Bay, WI |
TBD |
| Minnesota Vikings vs. St Louis Rams |
Metrodome Minneapolis, MN |
TBD |
| Buffalo Bills vs. St Louis Rams |
Ralph Wilson Stadium Buffalo, NY |
TBD |
| Miami Dolphins vs. St Louis Rams |
Sun Life Stadium Miami Gardens, FL |
TBD |
| Tampa Bay Buccaneers vs. St Louis Rams |
Raymond James Stadium Tampa, FL |
TBD |
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